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Novo Nordisk filed the New Drug Application (NDA) for CagriSema in early 2026, based on positive results from the REDEFINE phase 3 trial program

Although ORD studies of polypeptides and proteins were conducted prior to CD, the dominance of ORD lasted only a few years, as in 1960, a French group presented an innovative approach to measure CD based on the use of a Pockels cell as an electro-optic retardation modulator (Grosjean and Legrand, 1960), which in combination with the adoption of the photoelastic modulator in 1966 (Billardon and Badoz, 1966), led to the development of accurate CD instruments

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Studies indicate that individuals with lower B12 levels are more likely to be obese[2], even after accounting for factors like diet, lifestyle and medication use